Definitely Rene (Mallrats). She just has so much attitude; I love her!
Prue (Charmed) because I'm the big sister in my family and I could relate to some of her sisterly issues.
Cate Dove (Christmas Caper) because she's the black sheep of her family (kinda like me) and she's just cool.
Brenda Walsh (90210) because I could relate to her in more ways than I can count. I always had a lot of friends in high school, but somehow still felt like an outsider a lot of the time, my best friend stole my boyfriend in 10th grade, my parents were like the ONLY parents I knew who weren't divorced, I did a lot of the things Brenda did (plays, protests, etc). And I still get told that I'm a good person with a big heart, which is why I never doubted that Brenda was a good person.
*squishy hugs*